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Ferraro et al (1999) using in vivo microdialysis and put up mortem large performance liquid chromatography observed that modafinil raises extracellular glutamate while in the medial preoptic and posterior parts of the hypothalamus, though the area application of your GABAA receptor antagonist bicuculline, which raised basal glutamate stages, preven

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Modafinil raises dopamine while in the nucleus accumbens by means of inhibition of DAT in the animal and human Mind as other addictive waking medication [44,49,52]. Classification of modafinil being an addictive remains controversial. Modafinil present attainable setbacks of abuse and addiction Regardless that no cases have already been noted up to

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